C Patrick Reynolds Selected Research

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

1/2018	A Comprehensive Safety Trial of Chimeric Antibody 14.18 With GM-CSF, IL-2, and Isotretinoin in High-Risk Neuroblastoma Patients Following Myeloablative Therapy: Children's Oncology Group Study ANBL0931.
1/2018	Corrigendum: A Comprehensive Safety Trial of Chimeric Antibody 14.18 With GM-CSF, IL-2, and Isotretinoin in High-Risk Neuroblastoma Patients Following Myeloablative Therapy: Children's Oncology Group Study ANBL0931.
9/2010	Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.
6/2002	Antidisialoganglioside/granulocyte macrophage-colony-stimulating factor fusion protein facilitates neutrophil antibody-dependent cellular cytotoxicity and depends on FcgammaRII (CD32) and Mac-1 (CD11b/CD18) for enhanced effector cell adhesion and azurophil granule exocytosis.

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C Patrick Reynolds Research Topics

Disease

117	Neoplasms (Cancer) 09/2023 - 07/2003
73	Neuroblastoma 09/2023 - 06/2002
20	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2017 - 09/2007
17	Ewing Sarcoma (Sarcoma, Ewing) 01/2019 - 08/2004
16	Leukemia 05/2015 - 06/2007
10	Rhabdomyosarcoma 09/2022 - 06/2008
9	Hypoxia (Hypoxemia) 01/2019 - 04/2003
8	Osteosarcoma (Osteogenic Sarcoma) 01/2019 - 06/2008
6	Sarcoma (Soft Tissue Sarcoma) 09/2022 - 04/2008
6	Rhabdoid Tumor (Rhabdoid Tumors) 01/2021 - 05/2008
5	Residual Neoplasm 12/2014 - 08/2004
5	Glioblastoma (Glioblastoma Multiforme) 01/2014 - 06/2008
5	Neoplasm Metastasis (Metastasis) 09/2013 - 06/2003
4	Hypersensitivity (Allergy) 01/2018 - 09/2010
4	Wilms Tumor (Wilm's Tumor) 08/2012 - 05/2008
3	T-Cell Lymphoma (Lymphoma, T Cell) 01/2021 - 01/2017
3	Hypotension (Low Blood Pressure) 01/2018 - 03/2006
3	Pain (Aches) 11/2010 - 01/2009
2	Hypertriglyceridemia 01/2023 - 01/2021
2	Breast Neoplasms (Breast Cancer) 09/2022 - 10/2009
2	Colonic Neoplasms (Colon Cancer) 09/2022 - 02/2018
2	Carcinoma (Carcinomatosis) 09/2022 - 06/2008
2	Ataxia Telangiectasia (Louis Bar Syndrome) 09/2022 - 01/2021
2	Thrombocytopenia (Thrombopenia) 01/2021 - 03/2009
2	Fatigue 01/2021 - 01/2009
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2019 - 02/2018
2	Alveolar Rhabdomyosarcoma 01/2019 - 07/2008
2	Capillary Leak Syndrome 01/2018 - 09/2010
2	Fever (Fevers) 01/2018 - 04/2014
2	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 08/2017 - 01/2017
2	Necrosis 10/2015 - 04/2014
2	Disease Progression 04/2014 - 03/2009

Drug/Important Bio-Agent (IBA)

39	N- propyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (PPTP)IBA 01/2017 - 12/2007
26	FenretinideIBA 01/2023 - 07/2003
13	Isotretinoin (Accutane)FDA LinkGeneric 09/2023 - 06/2004
13	RetinoidsIBA 01/2021 - 07/2003
9	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 09/2010
9	Proteins (Proteins, Gene)FDA Link 12/2014 - 04/2005
8	Vincristine (Oncovin)FDA LinkGeneric 11/2016 - 07/2007
7	Messenger RNA (mRNA)IBA 01/2023 - 07/2007
7	Biomarkers (Surrogate Marker)IBA 09/2022 - 01/2013
7	Topotecan (Hycamtin)FDA LinkGeneric 02/2016 - 10/2007
7	Melphalan (Alkeran)FDA LinkGeneric 10/2015 - 09/2003
6	Irinotecan (Camptosar)FDA LinkGeneric 09/2022 - 03/2009
6	RNA (Ribonucleic Acid)IBA 01/2020 - 08/2004
6	ABT-737IBA 10/2014 - 09/2007
6	Cytotoxins (Cytolysins)IBA 12/2010 - 04/2004
5	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 03/2009
5	Interleukin-2 (IL2)IBA 01/2018 - 03/2006
5	Antineoplastic Agents (Antineoplastics)IBA 10/2016 - 04/2004
5	Monoclonal AntibodiesIBA 09/2013 - 03/2006
5	Etoposide (VP 16)FDA LinkGeneric 02/2011 - 09/2003
4	dinutuximabIBA 09/2023 - 09/2010
4	Histones (Histone)IBA 01/2023 - 01/2017
4	Phosphotransferases (Kinase)IBA 09/2022 - 06/2008
4	CeramidesIBA 01/2022 - 07/2003
4	Histone Deacetylase InhibitorsIBA 01/2021 - 07/2007
4	Cisplatin (Platino)FDA LinkGeneric 02/2018 - 01/2008
4	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2018 - 06/2002
4	PowdersIBA 01/2017 - 05/2007
4	Drug CombinationsIBA 11/2011 - 01/2005
4	AgarIBA 06/2007 - 01/2005
3	Telomerase (Telomerase Reverse Transcriptase)IBA 09/2022 - 08/2014
3	Vorinostat FDA Link 01/2021 - 09/2009
3	LigandsIBA 01/2017 - 09/2007
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 08/2004
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 02/2016 - 10/2007
3	Dexamethasone (Maxidex)FDA LinkGeneric 02/2016 - 09/2007
3	Buthionine SulfoximineIBA 10/2015 - 04/2003
3	CaspasesIBA 10/2014 - 09/2007
3	Sirolimus (Rapamycin)FDA Link 02/2011 - 04/2008
3	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2010 - 09/2003
3	lorukafusp alfaIBA 11/2010 - 06/2004
3	Carboplatin (JM8)FDA LinkGeneric 07/2007 - 09/2003
3	Trypan Blue FDA Link 06/2007 - 01/2005
2	CytokinesIBA 09/2023 - 01/2020
2	safingol (sphinganine)IBA 01/2023 - 08/2004
2	Cytochromes c (Cytochrome c)IBA 01/2022 - 09/2007
2	Alkylating AgentsIBA 01/2021 - 10/2015
2	Glutathione (Reduced Glutathione)IBA 01/2021 - 10/2015
2	BilirubinIBA 01/2021 - 07/2006
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 01/2017
2	Small Interfering RNA (siRNA)IBA 01/2021 - 07/2007
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 01/2017
2	venetoclaxIBA 12/2019 - 01/2018
2	EnzymesIBA 02/2018 - 02/2015
2	Capsules (Microcapsules)IBA 08/2017 - 11/2013
2	EmulsionsIBA 08/2017 - 04/2014
2	ProdrugsIBA 06/2015 - 09/2011
2	Oxygen (Dioxygen)IBA 05/2015 - 01/2005
2	talazoparibIBA 02/2015 - 01/2015
2	Surface Antigens (Surface Antigen)IBA 09/2013 - 09/2003

Therapy/Procedure

43	Therapeutics 09/2023 - 07/2003
19	Drug Therapy (Chemotherapy) 09/2023 - 06/2002
4	Immunotherapy 01/2020 - 09/2010
4	Radiotherapy 09/2013 - 01/2009
3	Stem Cell Transplantation 09/2013 - 01/2006
3	Bone Marrow Transplantation (Transplantation, Bone Marrow) 09/2013 - 07/2003
3	Chemoradiotherapy 09/2013 - 07/2003
3	Duration of Therapy 10/2012 - 07/2010